Vinay Kumar, MBBS, MD, FRCPath
Pathology Department, The University Of Chicago,
These 108 questions have been made by a group of people who came together on line to practice making good MCQs.The style chosen is one best answer and the goal was to make questions in a clinical context that test application of facts rather than rote memorization. The questions below are a mixture of those aimed at PGs and most aimed at UGs. Multipart questions can be converted into independent questions or fractional marking may be used. Thanks are due to all participants, the subeditors (Dr N Asokan, Dr Medha Joshi, Dr Fatima Zahra, Dr Umashankar T, and Dr CBSR Prasad) who helped me, and to our fearless leader Dr Sanjay Bedi for organizing this.
1. A 20 year female went on holiday to beach resort. Following the vacation her complexion became darker. Her skin did not show warmth, redness, itching or tenderness. Her skin complexion comes to its original tone within a month. Which of the following substance contributes the most to the biochemical process leading to these skin changes?
E. HOMOGENTISIC ACID
2.. A 45 year male presented with pallor, weakness and fatigability for the past 3 months. On examination he has a palpable spleen with lab investigations-WBC count -2 lac/cumm,Hb5.6gm/dl,platelets-60000/cumm.The PBF shows many mature and immature myeloid cells.Cytogenetic analysis of bone marrow cells show a translocation which leads to formation of a hybrid gene that increases tyrosine kinase activity. Which of the following genes is most likely translocated to cause these findings?