Assessment Tools for Dermatological Clinical Studies

C. P. Sharma1, Arun Kumar2*
1 Principal, Bakson Homoeopathic Medical College & Hospital, Greater Noida
2* Assistant Professor, Department of Homoeopathic Pharmacy, Bakson Homoeopathic Medical College & Hospital, Greater Noida

Abstract:
Dermatological clinical studies need to be reported in a uniform pattern utilizing various authenticated assessment tools. A lack of knowledge regarding availability of study instruments for the assessment of the various dermatological conditions results in poor quality study reports. Here is a list of dermatological study questionnaires which can aid the researchers to assess the disease condition and the efficacy of treatment appropriately.

Keywords: Dermatological clinical studies, Assessment tools, Homoeopathy, Quality of Life Questionnaires

Introduction:
Clinical studies are the backbone of evidence based researches in medicine. These studies can range from a single case report to a large sample studies. A case report is the smallest publishable unit in the medical literature consisting of detailed presentation of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient. Whereas a case-series is an aggregation of several similar cases, consisting of minimum three cases.[1,2] Dermatological cases are very frequently reported as they are widespread  throughout the world and have wide variety of presentation and treatment options available. Homoeopathy as an alternative method of treatment has extensive scope in the treatment of dermatological conditions due to availability of wide range of medicines for the treatment of various dermatological conditions and it also lacks side effects.

Most of the dermatological cases treated with different methods of treatment lack uniformity while reporting. For evidence based and quality reporting of the cases, certain standard quality assessment scales need to be used for the assessment of the case studies. Photographic evidence usually suffice for case reports but cannot be used in larger size case series and other clinical studies. This creates a need for various assessment scales for the quality and standard reporting of the studies.

In the present era of evidence based medicine, a wide range of assessment tools are available depending on the type of study. Lack of information regarding availability of assessment scales leads to poor quality reporting of clinical studies. Here we present a range of assessment scales for the reporting of dermatological clinical studies.

There are 4 types of instruments available for evaluation of the dermatological disorders [3,4,5]

  1. General Quality of Life questionnaires
  2. Dermatology specific Quality of Life questionnaires
  3. Disease- specific Quality of Life questionnaires
  4. Psychiatric effects of dermatological diseases questionnaires

The Quality of Life scales assesses impact of disease on quality of life of patient and deals with personal problems and need of the patient. General, Dermatology specific, Disease specific Quality of Life questionnaires are given under Table 1, 2 & 3 respectively. Tools for assessment of Psychiatric effects of Dermatological Disorders are given in Table 4.

Table 1. General Quality of Life Questionnaire’s [3,4,5]

Name of the Questionnaire

Authored by

  1. World Health Organization Quality of Life scale (WHO-QOL)

World Health Organization

  1. Visual Analog Scale- Itch (VAS)

Phan NQ et al. 2012, Verweyen et al 2019

  1. Short-form 36 Health Survey (SF-36)

Bullinger 1995

  1. Nottingham Health Profile

Hunt et al 1985

  1. EuroQOL Dimension (EQ-5D)

EuroQoL group, 1990

  1. UK Sickness Impact Profile

Salek et al 1996

  1. General Health Questionnaire

Goldberg 1972

Table 2: Dermatology specific Quality of Life Scale [3,4,5]

Name of the Questionnaire

Authored by

Additional Information

  1. Dermatology Life Quality Index[6]

Finlay & Khan 1994

Most frequently used. 110 translations have been done. In patients above 16 years of age. Consists of 10 questions.

  1. Dermatology Quality of Life Scales[7]

Morgan et al 1997

17 psychosocial items and 12 activities items were assigned five–point scales

  1. Dermatology specific Quality of Life Questionnaire[8]

Anderson 7 Rajgopalan 1997

  1. Skindex-29 [9]

Chren et al 1996

Original had 62-item which cannot be used. Skindex-29 is a revised 29-items version of Skindex. Skindex-16 is a single-page version of Skindex.

  1. Marburg Skin Questionnaire (MHF)

Stangier et al 1997

Marburger Hautfragebogen (MHF)

  1. Children’s Dermatology Life Quality Index (CDLQI)

Lewis-Jones and Finlay 1995

for children between 5 to 16 years of age

  1. Infant Dermatology of Life Quality Index (InToDermQoL)

Lewis Jones et al 2001

from birth to 4 years of age

  1. Adjustment of Chronic Skin Disorders

Stangier et al 2003

  1. Skin Satisfaction Questionnaire

Grolle et al 2003

an instrument for recording attitudes towards the skin in healthy persons and patients

  1. Questionnaire on Experience with Skin Complaints

Schmid – Ott et al 1996

especially for psoriasis and atopic dermatitis

Table 3: Disease specific Quality of Scale [3,4,5]

Name of The Questionnaire

Authored by

Disease condition

  1. Quality of Life Index for Atopic Dermatitis (QoLIAD) [10]

Whalley D et al 2004

Atopic Dermatitis

  1. Childhood Atopic Dermatitis Impact Scale (CADIS) [11]

Chamlin S et al 2007

Atopic Dermatitis in children

  1. Cardiff Acne Disability Index

Salek et al 1997

Acne

  1. Acne-specific Quality of Life Questionnaire (Acne-QoL) [12]

Girman CJ et al 2003

Acne

  1. Skin cancer Index (SCI) [13]

Sanchez S et al 2019

Non Melanoma Skin Cancer

  1. Functional Assessment of Cancer Therapy – Melanoma (FACT-M) [14]

Cormier J et al 2005

Melanoma

  1. Psoriasis Disability Index

Finlay & Kelly 1987

Psoriasis

  1. Psoriasis Life Stress inventory

Gupta and Gupta 1995

Psoriasis

  1. Psoriasis Specific Measure of Quality of Life

McKenna et al 2003

Psoriasis

  1. Scalpdex [15]

Chen et al 2002

Scalp disorders like scalp dermatitis, psoriasis, seborrheic dermatitis

  1. Chronic Urticaria Quality of Life Questionnaire (CU-2QoL) [16]

Baiardani I et al 2005

Chronic Urticaria

  1. Eczema Disability Index [17]

Salek M et al 1993

Eczema

  1. Freiburg  Quality  of  Life  Assessment [18]

Augustin M et al 2010

Wounds

  1. Dermatitis Family Impact Scale

Lawsen et al. 1998

Dermatitis

  1. Acne Disability Index

Motley and Finlay 1989

Acne

  1. Atopic Dermatitis

Herd et al 1997

Atopic Dermatits

  1. Itching Questionnaire

Yosipovitch et al 2002

Itching

  1. Leg Ulcer Questionnaire

Hyland 1994

Leg Ulcer

  1. Melasma Quality of Life Scale

Balkrishnan et al 2003

Melasma

  1. MIMIC Questionnaire

Leu 1985

Multidimensional especially psoriasis

  1. MM Module for Melanoma

Sigurdardotti et al 1993

Melanoma

  1. Vespid Allergy Quality of Life Questionnaire

Oude Elbrinke et al 2002

For allergies to bee and Wasp stings

Table 4: Tools to assess Psychiatric effects of Dermatological Disorders [5]

Name of the Questionnaire

Authored by

  1. Body Dysmorphic Disorder Questionnaire – Dermatology Version (BDDQDV)

Danesh M et al 2015

  1. Dysmorphic concern Questionnaire (DCQ)

Danesh M et al 2015

  1. Body Dysmorphic Symptom Scale (BDSS)

Danesh M et al 2015

DLQI is the most frequently used questionnaire in dermatological studies. Other scales are used as per the requirement and feasibility of the study. Many other dermatological study instruments are also available but are less frequently used. Choice of the questionnaire depends on the type of study, applicability and availability of scale, requirements of the study, language in which the scale is available and population to be studied.

Discussion & Conclusion:
A large number of questionnaires are available to the researchers and clinicians for different types of studies. There are disease-specific scales available for different dermatological conditions. In conditions where specific scale for disease condition is not available, a general questionnaire or dermatology specific scales can be used as per the requirement of the researcher and his study. As most of the dermatological disorders affect the appearance of the patient and hence have an effect on the psychology of the patient, in such cases specific scales for assessing psychological effects of the dermatological condition are also available.

References:

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