India to ban pentavalent vaccine due to reactions & deaths

mother2New Delhi: A leading Indian journal of medical ethics has charged the World Health Organization (WHO) with promoting a vaccine whose use has been discontinued in some countries following adverse reactions and deaths in children.

In a hard-hitting editorial, the Indian Journal of Medical Ethics (IJME) has accused the WHO of promoting pentavalent vaccine “by stating falsely that no adverse event following immunisation (AEFI) has ever been reported with the vaccine.” The journal says this is contrary to facts.

The IJME editorial says that on 4th May 2013 the Ministry of Health of Vietnam suspended Quinvaxem — the pentavalent combination used in that country — after 12 deaths and 9 other non-fatal serious adverse events. According to local news reports, all the babies who died were in good health prior to vaccination and had serious trouble breathing before dying shortly afterwards.

Serious adverse reactions and deaths have now been reported with pentavalent vaccine produced by other manufacturers and in a number of countries, the journal says. Bhutan, Sri Lanka and Pakistan have stopped using the vaccine, “following unexplained deaths soon after immunization.”

“In all the deaths being discussed in this editorial, the common factor has been that the children had received pentavalent vaccine and in most of them, this was followed by high fever, excessive crying and in some, there were convulsions before the child died,” the journal says expressing surprise at how the WHO “failed to see the unifying connection between the deaths” in the different countries.

The journal has also questioned the very rationale for introducing Hib vaccination in India where the incidence of Hib disease is very low. The editorial estimates that vaccinating 25 million babies could at best save 350 children from Hib meningitis and Hib pneumonia but “3125 children will die from vaccine adverse effects.”

The journal warns that when countries like Bhutan and Vietnam have taken action, it is imperative that India acts to protect the lives of its children. “To trivialize all these deaths as ‘coincidental deaths’ is hiding the real picture.” [Source]

1 Comment

  1. I having a research project on immunity and leading a group of six scientists. Under the heading–
    1. The effects of different substances, including ultrahigh diluted alcosols, on the production of immune proteins and/or regulation thereof in the human beings.
    2. The effects of ultrahigh diluted alcosols in the corresponding individuals who already have mutant gene/s known to produce a pathology similar to the pathology obtained in HPT,s with the same substance and the effects thereof in the regulation as well as in the production of immune proteins.
    Following scientist are working —
    Dr. S. HARIMANN1; Dr. VED PRAKESH MISHRA2; DR. GOVIND PRASAD UPADHYA3; DR. SUNIL PARSE4; DR. RASHMI SHUKLA5.
    Department of Medicine and Genetics; Datta Meghe Institute of Medical Sciences; Datta Meghe Immunological Research Lab Wardha, Maharashtra, India. Datta Meghe Deemed University, Wardha, Maharashtra, India
    I am inscribing following fact from my contribution —-
    Even if specific immunological reactivity entirely relies onto the maturity of various systems of the organism. Yet, the resistance of organism besides immune system is also determined by the activities of various immunoglobulins, namely, immunoglobulin G A M E and D. The immunological responses and immune machinery remain extremely diminutive, immature and weak in the neonates and infants; therefore, kind nature has offered an alternative means for the protection of life to the growing neonates and infants. The neonates and infants disregarding theirs systemic immaturity actively synthesize antibodies. The main antibody is IgG. It possesses antiviral activities as well as antibacterial antibodies and found in the maximum amount in neonates infants. Its share is about 80%-90% of total antitoxins. It is a micro-globulin of relatively low molecular weight and is capable of freely trans-passing through the human placental barrier. For this reason only, after the catabolism of this antibody in the mother, when her blood trans-passes through placenta and infuses fœtus, he obtain its contents. The fœtus besides obtaining its contents (IgG), as compliant, from the mother, also synthesizes it actively. The level of IgG decreases to a minimum degree at the age of 4-5 months. But, by virtue of its effective active synthesis, its level soon gets on again and boosted up gradually. The Immunoglobulin M (IgM) antibody shares about 10% of the total Immunoglobulins in the body. Although it doesn’t penetrate placental barrier and reaches to the fœtus through trans-placental route; however, it actively synthesized by the fœtus. It is a soluble antigen and antitoxin. It mostly found active against the bacteria rather than viruses. Its activities are less dynamic onto the viruses. Although Immunoglobulin A (IgA) also doesn’t pass through trans-placental barrier; yet, besides blood and lymph of the organism it is also found in the different secretions of the body. During GIT infections, it play an extremely crucial role as GALT. It also operate as protective in RS infections. Because, as a protectionist, besides providing general immunity to the organism it also provides local immunity, especially, during the GIT and RS infections. Though IgA and its antibodies, which found bonded with it, do not found congenitally in the blood of fœtous or neonatal blood; yet within 2-3 weeks soon after the birth of newborn its active synthesis begins in neonates and carried on even during the periods of artificial immunization with different antigens. Meanwhile IgM appears. It synthesized first after the production of IgG. Consequently, due to presence of mother’s antibodies in the neonatal blood as well as active production of them in the newborn babies, a fact, the BCG immunization doesn’t take effect positively well, which is inoculated soon after birth. As a result, due to failure of BCG immunization, tuberculosis is ever-increasing over the globe and prevailing in all the creatures. It’s failure of immunization schedule and policy thereof. Although synthesis of antibodies actively begins since the early stages of neonatal and infantile periods; yet, as theirs immune system still remains immature, the materialization of immunological response feebly appears in effect. It can be characterized as follows: 1. Despite prevalent synthesis of IgM, it does not ensure adequate protection to the organism. 2. The specific reaction to some antigens are found missing. 3. The strict specificity related to immune response as well as synthesis of the antibodies thereto corresponding antigen is altogether found missing. 4. In addition some other factors comparatively a very little amount of antibodies appear in the circulation, which are found responsible for the above phenomenal expressions.
    DR. S. HARIMANN
    INDIA

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