Chandragouda R Patil , Ajit R Gadekar , Pramit N Patel , Ashish Rambhade , Sanjay J Surana and Mahendra H Gaushal2
R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule, Maharashtra, India
Department of Medicine, KDMG’s Homeopathic Medical College and Hospital, Nimazari Road, Shirpur, Dhule, Maharashtra, India
Background: Toxicodendron pubescens is the current botanical name of homeopathic Rhus toxicodendron (Rhus tox). Rhus tox drug is widely used in homeopathically diluted form in the treatment of inﬂammatory and edematous conditions. We studied the effect of crude form of this plant, after single and multiple doses in Carrageenan induced paw inﬂammation in rats.
Method: We evaluated effects of single dose and multiple doses of orally administered Rhus tox on Carrageenan induced paw inﬂammation in rats. We tested 10 mg/kg, 20 mg/ kg and 40 mg/kg doses of Rhus tox.
In the single dose study, Rhus tox was administered 1 h prior to the subplantar injection of Carrageenan. In the multiple dose study, Rhus tox was administered twice daily for three days and Carrageenan was injected 1 h after the last dose. Paw volume was measured using a digital plethysmometer.
Results: Administration of a single dose of Rhus tox 1 h prior to injection of Carrageenan signiﬁcantly reduced the paw inﬂammation in a dose dependent manner. Administration of multiple doses of Rhus tox increased the intensity of inﬂammation induced by Carrageenan, but this was not statistically signiﬁcant.
Conclusion: Rhus tox, in crude form, exerts anti-inﬂammatory effects after a single dose and proinﬂammatory effect after multiple doses in Carrageenan induced paw inﬂammation in rats. Further study is needed to explain this dual effect.
Keywords: Toxicodendron pubescens; anti-inﬂammatory; proinﬂammatory; Carrageenan; dual effect; Rhus tox
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