Dual effect of Toxicodendron on Carrageenan induced edema rats

Chandragouda R Patil  , Ajit R Gadekar , Pramit N Patel  , Ashish Rambhade , Sanjay J Surana and Mahendra H Gaushal2

R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule, Maharashtra, India

Department of Medicine, KDMG’s Homeopathic Medical College and Hospital, Nimazari Road, Shirpur, Dhule, Maharashtra, India

Background:   Toxicodendron pubescens is the current botanical name of homeopathic Rhus toxicodendron (Rhus tox). Rhus tox drug is widely used in homeopathically diluted  form in the treatment of inflammatory and edematous conditions. We studied the effect   of crude form of this plant, after single and multiple doses in Carrageenan induced paw  inflammation in rats.

Method:  We evaluated effects of single dose and multiple doses of orally administered Rhus tox on Carrageenan induced paw inflammation in rats. We tested 10 mg/kg, 20 mg/  kg and 40 mg/kg doses of Rhus tox.

In the single dose study, Rhus tox was administered 1 h prior to the subplantar injection of Carrageenan. In the multiple dose study, Rhus tox was administered twice daily for  three days and Carrageenan was injected 1 h after the last dose.  Paw volume was measured using a digital plethysmometer.

Results:    Administration of a single dose of Rhus tox 1 h prior to injection of Carrageenan significantly reduced the paw inflammation in a dose dependent manner. Administration of multiple doses of Rhus tox increased the intensity of inflammation induced by Carrageenan, but this was not statistically significant.

Conclusion:      Rhus     tox,   in   crude     form,  exerts    anti-inflammatory effects   after  a  single    dose    and   proinflammatory          effect   after  multiple     doses    in  Carrageenan induced  paw inflammation in  rats. Further study is needed to explain this  dual  effect.

Keywords: Toxicodendron  pubescens; anti-inflammatory; proinflammatory;  Carrageenan; dual effect; Rhus tox

Download full paper : www.homeobook.com/pdf/dual-effect-rhustox.pdf

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