Preventive and curative protocol for homoeopathy in COVID-19 Kerala

Preventive and curative protocol for homoeopathic management of COVID-19 – Proposal submitted to Kerala CM based on scientific facts and research papers of the non-homoeopathic scientist – this article clearly stating Why and How Ars.alb improving the immunity. 

Prepared by
Advanced Research Laboratory, DRW & Research in Homoeopathy,
Homoeopathic Medical Education,Department of AYUSH, Government of Kerala
Thiruvananthapuram – 695009 

In the current scenario of COVID-19 pandemic outbreak, we are proposing a protocol in collaboration with Homoeopathy Department and National AYUSH Mission to improve the immunity of people residing in Kerala. Rapid Action Epidemic Control Cell Homoeopathy (RAECH), Kerala, was constituted as per GO(Rt) No: 2543/04/H & FWD dated 07/09/2004. This cell was inaugurated on 15.12.2004 under Department of Homoeopathy. Epidemic Control Measures are being initiated under the supervision of RAECH by distributing preventive medicines, conducting medical camps, health awareness programmes and seminars throughout the State, during the periods of epidemic outbreaks. During the past epidemic outbreaks Department of Homoeopathy and Homoeopathic Medical Education have successfully conducted various immunization programmes to support the public health interventions in Kerala.In this regard, we are proposing a protocol for enhancing the immunity of people in Kerala by using Homoeopathic medicinal interventions as follows, 

Preventive and immuno booster approach:
According to the recommendations of the Central AYUSH Ministry we propose to use Arsenicum Album 30 (Ars. Alb.30) for prophylaxis. By upgrading the immunological memory of human beings using an external stimulus through lipid functionalized As2O3 (Ars. Alb), we can improve the specific immunity of the public against SARS-CoV-2. Ars. Alb is a well-established drug for clinical management of diseases with presenting symptoms similar to COVID-19. As2O3 is widely used in modern medicine and nanomedicine trials for improving immunity and reduce inflammation due to immunocompromised diseases 1-10. In homoeopathic pharmacopeia of India, the preparation of Ars.Alb. is clearly mentioned and Ars.Alb. 30 is considered as an established drug derived from mineral sources which can deliver therapeutic action at nanomaterial dose10-15.

More importantly, As2O3 and its various formulations have a significant role in PML isoforms and these PML gene regulations have crucial role in generating antiviral defence mechanism12. In the context of COVID-19 pandemic outbreak As2O3 based homoeopathic prophylaxis will help the human body to experience immunological learning from artificial immune challenge raised through Ars.Alb. Glycerin present in Ars. Alb. elevates the blood plasma osmolality thereby extracting water from tissues into interstitial fluid and plasma, which in turn helps the associated As2O3 to perforate through the cell membranes. 

Thus, the Ars.Alb. entered into the cellular environment will create an immunological stress15-20. The body will auto-activate the defensive mechanism to fight this immunocompromised situation and these quantum biological variations will manifest as the symptom picture of Ars. Alb. As per homoeopathic prophylaxis we use Ars.Alb. compound due to its similarity with symptoms manifested in COVID-19 infected patients. Which depicts that the person subjected to homoeopathic prophylaxis will develop an immune memory which can defend against the SARS-CoV-2 virus. In conclusion, we propose a highly effective, safe and economically viable personalized, precision intervention to improve the immunity of common public. Ars.Alb is used as an CDSCO approved drug in India without any contraindications till date. In conclusion, we propose a statewide homoeopathic prophylaxis for preventing the COVID-19 pandemic outbreak. It can be carried out in accordance with the COVID-19 protocol in collaboration with Local Self Government Departments through ASHA workers, KUDUMBA SREE members, selected health workers and volunteers. The fund required for the activities can be mobilized with the help of National AYUSH Mission, Local Self Government Departments and Plan Funds. 

An integrated approach for clinical management
COVID19-Homoeopathic Mission Monitoring Team will be constituted under the SLEG. Homoeopathic Expert Team will be formed based on the SLEG recommendations. Standard homoeopathic medicinal intervention protocol will be adopted for managing the clinical conditions with presenting symptoms similar to the symptoms of COVID-19. 

Laboratory diagnosis:
It is recommended to measure the baseline values of CBC,RFT,LFT,CRP,RBS,ECG,USG,PFT, BP, RR, PFT, ESR, procalcitonin, ferritin, D -dimer, total and subpopulations of lymphocytes, IL-4, IL-6, IL-10, TNF-α, INF-α, LDH, CK-MB, Troponinsand other indicators of inflammation and immune status, which can help evaluate clinical progress, alert severe and critical tendencies, and provide a basis for the formulation of treatment strategies. Most patients with COVID-19 have a normal level of procalcitonin with significantly increased levels of (-reactive protein. A rapid and significantly elevated C-reactive protein level indicates a possibility of secondary infection. D -dimer levels are significantly elevated in severe cases, which is a potential risk factor for poor prognosis. Patients with a low total number of lymphocytes at the beginning of the disease generally have a poor prognosis. Severe patients have a progressively decreased number of peripheral blood lymphocytes. The expression levels of IL-6 and IL-10 in severe patients are increased greatly. Monitoring the levels of IL-6 and IL-10 is helpful to assess the risk of progression to a severe condition. Severe and critically ill patients are vulnerable to secondary bacterial or fungal infections. Early diagnosis, treatment and isolation should be carried out whenever possible. Dynamic monitoring of lung imaging, oxygenation index and cytokine levels are helpful for early identification of patients who may develop into severe and critical cases. 

Clinical diagnosis:
Clinical diagnosis is based on symptom analysis, symptom picture group analysis and symptom dynamics during homoeopathic medicinal intervention based on standard homoeopathic medicinal intervention protocol. 

Standard Homoeopathic Medicinal Intervention Protocol (SHMIP):
SHMIP is based on classical homoeopathic approach. The symptoms of the patient will be diagnosed through observations and questions. These symptoms are grouped into different categories and the medicines indicated for the obtained symptom picture is identified and prescribed according to the susceptibility of patient. The dose of the medicine is determined based on the severity of symptoms which can be corelated to the laboratory diagnosis. The cure is determined by the complete relief from symptoms which can be identified from the standard laboratory diagnosis data by comparing to the corresponding baseline values. 

Drugs used:
All the drugs used in Homoeopathic medicinal interventions are approved by CDSCO and listed in Homoeopathic pharmacopeia of India. Till date there no contraindications are reported for the drugs listed in this protocol. See the full paper for details of the administration of medicine.


  1. N. Charan, et al., Antiviral activity of antimony and arsenic oxides, Der Pharma Chemica, 2012, 4 (2):687-689
  2. Myung-Jin Park, et al., Arsenic Trioxide (As2O3) Inhibits Invasion of HT1080 Human Fibrosarcoma Cells: Role of Nuclear Factor-kB and Reactive Oxygen Species, Journal of Cellular Biochemistry 95:955–969 (2005)
  3. Qian C, Wang Y, Chen Y et al. Suppression of pancreatic tumor growth by targeted arsenic delivery with anti-CD44v6 single chain antibody conjugated nanoparticles. Biomaterials 34(26), 6175–6184 (2013).
  4. She-Ling Xie, et al., Efficacy of Arsenic Trioxide in the Treatment of Malignant Pleural Effusion Caused by Pleural Metastasis of Lung Cancer, Cell BiochemBiophys, DOI 10.1007/s12013-014-0352-3
  5. Xinxin Yang, et al., Arsenic trioxide induced endoplasmic reticulum stress in laryngeal squamous cell line Hep-2 cells, Auris Nasus Larynx 41 (2014) 81–83
  6. Shing Hwa Liu, et al., Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway,PLOS ONE, DOI:10.1371/journal.pone.0137907
  7. Lin-Fu Zhou, et al., Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen- induced airway hyperresponsiveness and inflammation,Respiratory Research 2006, 7:146 doi:10.1186/1465-9921-7-146
  8. Lingyan W., et al., Arsenic trioxide and sorafenib combination therapy for human hepatocellular carcinoma functions via up‐regulation of TNF‐related apoptosis‐inducing ligand, Oncology Letters, 16: 3341-3350, 2018.
  9. Nolan K. Maier, et al., Arsenic Trioxide and Other Arsenical Compounds Inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 Inflammasomes, The Journal of Immunology,
  10. Leonidas C., Platanias, Biological Responses to Arsenic Compounds, The Journal of Biological Chemistry Vol. 284, NO. 28, pp. 18583–18587, July 10, 2009 DOI 10.1074/jbc.R900003200
  11. Lionel Berthoux, et al., As2O3 Enhances Retroviral Reverse Transcription and Counteracts Ref1 Antiviral Activity,Journal of Virology, Mar. 2003, p. 3167–3180
  12. Marion Jeanne, et al., PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3, DOI 10.1016/j.ccr.2010.06.003.Cancer Cell 18, 88– 98.
  13. HadiGhaffari, et al., Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine, Journal of Biomedical Science (2019) 26:70
  14. Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013;369:111–121.
  15. Yolanda S. et al., Arsenic trioxide as an anti-tumour agent: mechanisms of action and strategies of sensitization, Appl Biomed 8:199–208, 2010.
  16. Xue-Qing Hu, et al., Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer, Current Cancer Drug Targets, 2016, 16, 346-356
  17. Kuan-Hua Chu, et al., Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma, Cellular & Molecular Immunology (2010) 7, 375–380
  18. Yan Wang, et al., Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/β-catenin signaling pathway in Jurkat cells, Experimental and Therapeutic Medicine 13: 2050-2055, 2017
  19. Radhakrishnan C.V., et al., L-Ascorbic Acid and a-Tocopherol Synergistically Triggers Apoptosis Inducing Antileukemic Effects of Arsenic Trioxide via Oxidative Stress in Human Acute Promyelocytic Leukemia Cells, Frontiers in oncology,doi: 10.3389/fonc.2020.00065
  20. Liang Shi, et al., Arsenic trioxide inhibits cell growth and elevates T cell subgroup of bladder cancer in vitro and in vivo, Int J Clin Exp Pathol 2016;9(1):244-249

Download full paper 


  1. But why do we need all these tests?

    A good clinicuan is all that is nèeded for a day to day progress of the illness

    Homoeopathy does not go by laboratory tests, but by clinical assessment including history

  2. sir
    how we can get covid 19 preventive medicine from cuba.
    is it possible bring the medicine in India.

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