Differential Diagnosis of Hepatosplenomegaly

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abdomenDr Ameer Khalid

Acromegaly … enlarged spleen, enlarged liver
Autoimmune Hepatitis … enlarged liver
Autoimmune Lymphoproliferative Syndrome … enlarged spleen, enlarged liver
Autoimmune Thrombocytopenia … enlarged spleen
Brucellosis … enlarged spleen, enlarged liver
Chagas disease … Hepatosplenomegaly

  • Chronic Granulomatous Disease … enlarged spleen, enlarged liver
  • Chronic Hepatitis C … Enlarged spleen, Enlarged liver
  • Cirrhosis of the liver … Enlarged spleen, Enlarged liver
  • Classic galactosemia … enlarged liver
  • Common Variable Immunodeficiency … enlarged spleen
  • Congenital syphilis … swollen liver, swollen spleen
  • Congenital Toxoplasmosis … enlarged spleen, enlarged liver
  • Cystic Fibrosis … enlarged spleen, enlarged liver
  • Gaucher Disease … spleen enlargement, liver enlargement, liver enlargement, liver enlargement
  • Hepatoma … enlarged spleen
  • Hyper-IgM Syndrome … enlarged spleen, enlarged liver
  • Infantile Refsum Disease … hepatomegaly (enlargement of the liver)
  • Leishmaniasis … enlarged spleen, enlarged liver
  • Leukemia … Swollen liver, Swollen spleen
  • Liver abscess … enlarged liver
  • Liver cancer … enlarged liver
  • Lupus … enlarged spleen
  • Lymphoma … enlarged spleen, enlarged liver
  • Malaria … Splenomegaly, Hepatomegaly
  • Mononucleosis … enlarged spleen, enlarged liver
  • Mucopolysaccharidosis VII … spleen enlargement, liver enlargement
  • Neonatal ALD … hepatomegaly (enlarged liver)
  • Niemann-Pick disease … spleen enlargement, liver enlargement
  • Non-Hodgkin’s Lymphoma … enlarged spleen, enlarged liver
  • Polycythemia … enlarged spleen, enlarged liver
  • Portal hypertension … enlarged spleen
  • Relapsing fever … enlarged spleen, enlarged liver
  • Reye’s Syndrome … enlarged liver
  • Right heart failure … enlarged liver
  • Schistosomiasis … enlarged liver, hepatosplenomegaly
  • Sickle Cell Anemia … enlarged spleen, enlarged liver
  • Systemic Juvenile Rheumatoid Arthritis … enlarged spleen
  • Thalassemia … mild spleen enlargement, spleen enlargement, liver enlargement
  • Thrombocytopenia … enlarged spleen
  • Toxocariasis … Enlarged spleen, Enlarged liver
  • Typhoid fever … splenomegaly, enlarged liver
  • Vitamin A overdose … enlarged spleen, enlarged liver
  • Weil’s syndrome … hepatomegaly
  • Wilson’s Disease … swollen liver, swollen spleen
  • Zellweger Syndrome … enlarged liver